Targeted destruction of pests

Details Targeted destruction of pests Targeted destruction of pests

2006-03-14

2006-03-14

Nolan, Patrick J. (Department: 1644)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

C530S387300, C530S391700

Reexamination Certificate

active

07011835

ABSTRACT:
The present invention is drawn to a safe, cost-effective, environmentally-friendly and ecologically-sound bioengineered pest eradication product and uses thereof. Immunological and genetic engineering techniques are used to generate monoclonal antibodies as well as viruses (phage) that display scFv heavy and/or light chain Ig fragments which exhibit high-avidity specific binding to cells of the microvilli of the midgut of imported fire ant queens. The specific monoclonal antibodies and phage displayed antibody Fab fragments are conjugated to a toxin for targeted delivery and destruction of imported fire ant queens, but not native species.

REFERENCES:
patent: 5686600 (1997-11-01), Carozzi et al.
patent: 5837242 (1998-11-01), Holliger et al.
patent: 5870852 (1999-02-01), Stanley

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