Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1997-01-23
1999-03-09
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424501, 424423, 514 2, 514 21, 514964, 514965, 514824, A61K 916, A61K 3818, A61K 3819
Patent
active
058797130
ABSTRACT:
Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the cells where delivery is desired, where the bioactive molecule is encapsulated in a vehicle such as liposomes which facilitates transfer of the bioactive molecules into the targeted tissue. Targeting of the bioactive molecules can also be achieved by selection of an encapsulating medium of an appropriate size whereby the medium serves to deliver the molecules to a particular target. For example, encapsulation of nucleic acid molecules or biologically active proteins within biodegradable, biocompatible polymeric microparticles which are appropriate sized to infiltrate, but remain trapped within, the capillary beds and alveoli of the lungs can be used for targeted delivery to these regions of the body following administration to a patient by infusion or injection.
REFERENCES:
patent: 3663687 (1972-05-01), Evans
patent: 4345588 (1982-08-01), Widder
Battler in JACC 22 #7 p. 2001, Dec. 1993.
Molecular Cell Biology Ed. by Darnell, Lodish & Baltimore Scientific American Books p. 132, 1986.
Herman Stephen Jack
Roth Laurence A.
Focal, Inc.
Kishore Gollamudi S.
LandOfFree
Targeted delivery via biodegradable polymers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Targeted delivery via biodegradable polymers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Targeted delivery via biodegradable polymers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1318236