Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification
Reexamination Certificate
2007-06-05
2007-06-05
Angell, Jon E. (Department: 1635)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
C435S455000, C435S463000, C435S471000
Reexamination Certificate
active
10261185
ABSTRACT:
Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base analogs.
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Gamper Howard B
Kmiec Eric B
Rice Michael C
McCarter & English
University of Delaware
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