Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-08-30
2005-08-30
Nguyen, Dave T. (Department: 1635)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S440000, C435S463000, C435S471000, C435S006120, C536S023100, C536S024200, C536S024300
Reexamination Certificate
active
06936467
ABSTRACT:
Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base analogs.
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Gamper Howard B.
Kmiec Eric B.
Rice Michael C.
Angell Jon Eric
Becker Daniel M.
Heller Ehrman White & McAuliffe LLP
Nguyen Dave T.
University of Delaware
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