Targeted carrier fusions for delivery of chemotherapeutic...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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Reexamination Certificate

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07122353

ABSTRACT:
The present invention provides for fusion proteins that act as targeted drug carries. The proteins are derived from molecules that possess natural drug-binding capabilities that are further engineered to target specific cell types, and optionally to have altered/improved drug binding characteristics. These fusion proteins are useful in, for example, delivery of chemotherapeutic compounds to cancer cells.

REFERENCES:
patent: 2002/0182671 (2002-12-01), Lal et al.
patent: 2005/0042753 (2005-02-01), Yang et al.
patent: WO 87/02061 (1987-04-01), None
patent: WO 95/03064 (1995-02-01), None
patent: WO 98/10795 (1998-03-01), None
patent: WO 01/53342 (2001-07-01), None
Aina et al., “Therapeutic cancer targeting peptides,”Pept. Sci.,66:184-199, 2002.
Martin et al., “Molecular basis of mitomycin C resistance in Streptomyces: structure and function of the MRD protein,”Structure, 10:933-942, 2002.
Shen et al., “Enediyne natural products: biosynthesis and prospect towards engineering novel antitumor agents,”Current Medicinal Chemistry, 10(1):1241-1253, 2003.
Sugiyama et al., “The 1.6-Å crystal structure of the copper(II)-bound bleomycin complexed with the bleomycin-binding protein from bleomycin-producing streptomyces verticillus,”J. Biol. Chem.,277(3):2311-2320, 2002.
Tanaka et al., “Solution structures of C-1027 apoprotein and its complex with the aromatized chromophore,”J. Mol. Biol.,309:267-283, 2001.
Thornson et al., “Enediyne biosynthesis and self-resistance: a progress report,”Bioorganic Chemistry, 27(2):172-188, 1999.
Sheldon et al., “Characterization of a mitomycin-binding drug resistance mechanism from the producing organism,streptomyces lavendulae,” J. Bacter.,179(5):1796-1804, 1997.

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