Targeted bisplatinum polyamines as pro-drugs: selective...

Details Targeted bisplatinum polyamines as pro-drugs: selective... Targeted bisplatinum polyamines as pro-drugs: selective...

2002-08-22

2009-08-25

O'Sullivan, Peter G (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

C514S483000, C514S492000, C556S137000

Reexamination Certificate

active

07579373

ABSTRACT:
Pro-drug forms of linear polyamine-bridged platinum compounds and methods for their production and use are provided. The polyamine-bridge portion of the compounds is based on spermine or spermidine, and the central amines of the polyamine-bridge are chemically bonded to labile blocking groups. The presence of the blocking groups serves to minimize the toxicity of the Pt compounds upon administration. Selective removal of the blocking groups and release of the active, unblocked species occurs upon exposure to suitable environmental conditions.

REFERENCES:
patent: 4797393 (1989-01-01), Farrell et al.
patent: 6022892 (2000-02-01), Farrell et al.
patent: 0109149 (2001-08-01), None
Holger Rauter et al. Selective Platination of Biologically Relevant Polyamines, Linear Coordinating Spermidine and Spermine as Amplify Linkers in Dinuclear Platinum Complexes, Inorganic Chemesty 1997, 36, pp. 3919-3927.

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