Targetable vector particles

Details Targetable vector particles Targetable vector particles

1995-06-07

1999-11-16

Degen, Nancy

Chemistry: molecular biology and microbiology

Vector, per se

435325, C12N 1563

Patent

active

059856556

ABSTRACT:
A vector particle (e.g., a retroviral vector particle) containing a chimeric envelope includes a receptor binding region that binds to a receptor of a target cell. The receptor of the target cell is other than the amphotropic cell receptor. The receptor binding region may be a receptor binding region of a human virus. A portion of the envelope gene may be deleted and the deleted portion is replaced with another receptor binding region or ligand. Such vector particles are targetable to a desired target cell or tissue, and may be administered directly to the desired target cell or tissue as part of a gene therapy procedure, or administered directly into the patient.

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