Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-06-06
2006-06-06
Wessendorf, T. D. (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S006120, C435S005000, C435S004000, C435S091500, C435S091500, C536S023400, C536S023100, C536S063000, C536S063000
Reexamination Certificate
active
07056679
ABSTRACT:
The invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages of a target or target library and a target-binder library, and selecting to eliminate the non-paired targets and binders. The invention also relates to antibodies that bind to complexes of target and target binders; nucleic acids encoding target and target binders peptides; and the use of sequence information inherent in the targets and target binders for target validation using in silico approaches. The invention further relates to diagnostics and therapeutics employing the disclosed target and target binder peptides or polynucletides and their use in small molecule drug discovery; diagnostic and therapeutic applications directed to cancers and similar disorders; and site directed assays for high throughput drug screening.
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PCT International Search Report dated Jun. 4, 2004.
Blume Arthur
Brissette Renee
Dedova Olga
Goldstein Neil
Pillutla Renuka
Antyra Inc.
Morgan & Finnegan , LLP
Wessendorf T. D.
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