Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1995-06-05
1998-01-06
Feisee, Lila
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241831, 4242361, 435 691, 435 697, 435 713, 435875, 5303873, 5303917, 530356, A61K 39104, C07K 300
Patent
active
057051631
ABSTRACT:
A target-specific, cytotoxic, recombinant Pseudomonas exotoxin is described. Such toxins are made by inserting specific recognition molecules at specific cloning sites in at least domain III near the carboxyl terminus of the PE molecule. Various modifications of the carboxyl terminus of the PE molecule to increase cytotoxicity are set forth. Multifunctional, recombinant, cytotoxic fusion proteins containing at least two different recognition molecules are provided for killing cells expressing receptors to which the recognition molecules bind with specificity. Methods for producing novel recombinant PE molecules with specific properties are described.
REFERENCES:
Thrush, G.R. et al. 1996. Ann. Rev. Immunol. 14: 49-71.
Osband, M.E. et al. 1990. Immunology today 11: 193-195.
Ozols, R.F. 1995 Tu: Current Problems in Cancer, vol. XIX, No. 4, 187-262.
Chaudhary Vijay K.
FitzGerald David
Pastan Ira
Davis Minh-Tam
Feisee Lila
The United States of America as represented by the Department of
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