Target-specific cytotoxic liposomes

Details Target-specific cytotoxic liposomes Target-specific cytotoxic liposomes

1987-02-09

1990-05-15

Teskin, Robin L.

Drug, bio-affecting and body treating compositions

Lymphokine

424 858, 424417, 424420, 424450, 435 29, 264 41, 264 43, 264 46, 530387, A61K 3900, C12Q 102

Patent

active

049256610

ABSTRACT:
The A fragment of the diphtheria toxin (DTA) was encapsulated in pH-sensitive liposomes. This novel reagent is extremely cytotoxic to cells expressing surface antigen which is recognized by the immunoliposome. The reagent is not toxic to cells which do not express the antigen. Thus, this reagent, or others similarly prepared represent potential anticancer reagents.

REFERENCES:
patent: 4789633 (1988-12-01), Huang et al.
Straubinger et al., J. Cell Biol., vol. 97, 109(9), Abst. No. 420, 1983.
Huang et al., Biochim Biophys Acta, vol. 716, 1982, pp. 140-150, "Characterization of Antibody Covalently Coupled to Liposomes".
Jansons, Chem. Abst., vol. 101(18), Abst. 1574939, "Preparation and Analysis of Antibody-Tangible Liposomes".

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