Target-specific compomers and methods of use

Details Target-specific compomers and methods of use Target-specific compomers and methods of use

2011-01-11

2011-01-11

Kapushoc, Stephen (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C435S287200, C435S320100, C536S023100, C536S024100, C536S024300

Reexamination Certificate

active

07867714

ABSTRACT:
Provided herein are libraries of nucleic acid species each comprising a transcription unit having a promoter region operatively linked to a coding sequence. The coding sequence of each nucleic acid species encodes a RNA cleavage substrate comprising a unique compomer species and a cleavage site. Each compomer species has a molecular mass distinguishable from the molecular mass of other compomer species in the library, and cleavage at a cleavage site releases a polynucleotide comprising the compomer species from the RNA cleavage substrate.

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