Target recognizing binding agents

Details Target recognizing binding agents Target recognizing binding agents

2005-12-13

2005-12-13

Weber, Jon (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C514S012200, C435S069100

Reexamination Certificate

active

06974860

ABSTRACT:
The invention is directed to binding agents having binding loops and a stable beta barrel conformation. The binding loops of these agents can easily be altered so that the binding agent can bind any selected target molecule. A variety of methods for generating binding agents with different binding loops are also provided.

REFERENCES:
patent: 6670453 (2003-12-01), Frenken et al.
Hamers-Casterman, C., et al., “Naturally Occuring Antibodies Devoid of Light Chains”,Nature, 363, (Jun. 3, 1993), 446-448.
McDonnell, J.M., “Surface Plasmon Resonance: Towards an Understainding of the Mechanisms of Biological Molecular Recognition”,Current Opinion in Chemical Biology, 5, (Jun., 2001), 572-577.
Alzari, P. M., et al., “Three-Dimensional Structure of Antibodies”,Annual Review of Immunology,6, (1988), 555-580.
Arnold, Ulrich, et al., “Kinetic and Thermodynamic Thermal Stabilities of Ribonuclease A and Ribonuclease B”,Biochemistry, 36, (1997), 2166-2172.
Clark, Matthew, et al., “Validation of the General Purpose Tripos 5.2 Force Field”,Journal of Computational Chemistry, 10(8), (1989), 982-1012.
Guex, Nicolas, “Swiss-MODEL and the Swiss Pdb Viewer: An environment for comparative protein modeling”,Electrophesis, 18, (1997), 2714-2723.
Hamers-Casterman, C., et al., “Naturally occurring antibodies devoid of light chains”,Letters to Nature, 363, (Jun., 1993), 446-448.
Higgins, Desmond G., “Clustal V: improved software for multiple sequence alignment”,Computer applications in the biosciences, 8(2), (1992), 189-191.
McDonnell, J. M., “Surface plasmon resonance towards an understanding of the mechanisms of biological molecular recognition”,Current Opinion Chemical Biology, 5, (2001), 572-577.
Muyldermans, Serge, “Single domain camel antibodies: current status”,Reviews in Molecular Biotechnology, 74, (2001), 277-302.
Oliphant, Arnold R., et al., “Cloning of random-sequence oligodeoxynucleotides”,Gene, 44, (1986), 177-183.
Pace, C. Nick, “Measuring the conformational stability of a protein”,In Protein Structure: A Practical Approach, Chapter 13, (1989), 311-330.
Peitsch, Manuel C., et al., “Automated Modelling of the Transmembrance Region of G-protein Coupled Receptor by Swiss-Model”,Receptors and Channels,4, (1996), 161-164.
Peitsch, M.C., “ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling”,Biochemical Society Transactions, 24, (1996), 274-279.
Sayle, Roger A., “RASMOL: biomolecular graphics for all”,Trends in Biochemical Sciences,20, (1995),333-379.
Siegel, Lewis M., “Determination of Molecular Weights and Frictional Ratios of Proteins . . .”,Biochemica Et Biophysica Acta, vol. 112, (1966), 346-362.

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