Organic compounds -- part of the class 532-570 series – Organic compounds – Thiosulfonic acids or salts thereof
Reexamination Certificate
2004-11-30
2010-02-09
Huff, Sheela J (Department: 1643)
Organic compounds -- part of the class 532-570 series
Organic compounds
Thiosulfonic acids or salts thereof
C562S030000, C562S037000, C562S058000, C562S088000, C514S708000, C514S709000
Reexamination Certificate
active
07659426
ABSTRACT:
The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound that specifically binds to KSRP or a functional fragment thereof, and a screening method for the compound. KSRP is a novel target protein for anticancer agents; a compound capable of regulating the expression and activity of such a protein and a pharmaceutical composition containing it are highly useful for proliferative diseases, particularly as anticancer agents. By providing the novel target protein, the mechanism behind the anticancer effect that has conventionally been unexplainable can be elucidated.
REFERENCES:
patent: 3654349 (1972-04-01), Shen et al.
patent: 3692651 (1972-09-01), Sletzinger et al.
patent: 5466823 (1995-11-01), Talley et al.
patent: 5756529 (1998-05-01), Isakson et al.
patent: 6200771 (2001-03-01), Liu et al.
patent: 6500610 (2002-12-01), Pamukcu et al.
patent: 53-12512 (1978-05-01), None
patent: 57-27107 (1982-06-01), None
patent: 9-506350 (1997-06-01), None
patent: 11-94823 (1999-04-01), None
patent: 11-514991 (1999-12-01), None
patent: 2000-186047 (2000-07-01), None
Sherman et al Cancer Research vol. 43 p. 4283 (1983).
Rehbein et al Journal of Neurochemistry vol. 82 p. 1039 (2002).
Min et al Genes and Development vol. 11 p. 1023 (1997).
Piazza et al., “Apoptosis Primarily Accounts for the Growth-inhibitory Properties of Sunlindac Metabolites and Involves a Mechanism That Is Independent of Cyclooxygenase Inhibition, Cell Cycle Arrest, and p53 Induction,”Cancer Research, 57: 2452-2459 (1997).
Piazza et al., “Sulindac Sulfone Inhibits Azoxymethane-induced Colon Carcinogenesis in Rats without Reducing Prostaglandin Levels,”Cancer Research, 57: 2909-2915 (1997).
Haramura Masayuki
Tanaka Akito
Terada Tomohiro
Tsutsumi Takeshi
Yamazaki Akira
Barnes & Thornburg LLP
Devadas Sandil K.
Huff Sheela J
Reverse Proteomics Research Institute Co., Ltd.
LandOfFree
Target protein of anticancer agent and novel anticancer... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Target protein of anticancer agent and novel anticancer..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Target protein of anticancer agent and novel anticancer... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4167582