Target protein and target gene in drug designing and...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007800

Reexamination Certificate

active

08058009

ABSTRACT:
The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. To be specific, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.

REFERENCES:
patent: 2002/0119929 (2002-08-01), Bishop et al.
patent: 2004/0115726 (2004-06-01), Nagashima et al.
patent: 2004-509406 (2004-03-01), None
patent: WO 03/087768 (2003-10-01), None
Brown et al.,Drug Discovery Today, 8(23): 1067-1077 (Dec. 2003).
Dimasi,Clinical Pharmacology&Therapeutics, 69(5): 297-307 (May 2001).
Drews,Science, 287: 1960-1964 (Mar. 17, 2000).
Frantz et al.,Nature Reviews, 2: 95-96 (Feb. 2003).
Fujii et al.,Chem-Bio Informatics Journal, 1(1): 18-22 (2001).
Hopkins et al.,Nature Reviews, 1: 727-730 (Sep. 2002).

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