Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-09-22
1996-06-18
Mosher, Mary E.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
536 237, 4353201, 4352523, 4352542, 435 693, 935 12, 935 65, C12N 1530, C12N 121, C12N 119, C12N 510
Patent
active
055277004
ABSTRACT:
The present invention relates novel methods and compositions for blocking transmission of Plasmodium spp. which cause malaria. In particular, P28 proteins are disclosed which, when administered to a susceptible organism, induce an immune response against a 28 kD protein on the surface of Plasmodium ookinetes and block transmission of malaria.
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Wizel, Benjamin, et al. (1991) "Identication of a continuous and cross-reacting epitope for Plasmodium falciparum transmission-blocking immunity", Proc. Natl. Acad. Sci. USA, 88:9533-9537.
Elliot, John Francis, et al., (1990) "Genes for Plasmodium falciparum surface antigens cloned by expression in COS cells", Proc. Natl. Acad. Sci USA, 87:6363-6367.
Grotendorst, Cynthia A., et al. (1984) "A Surface Protein Expressed During Transformation of Zygotes of Plasmodium gallinaceum is a Traget of Transmission-Blocking Antibodies", Infection and Immunity, 45(3):775-777.
Duffy, Patrick E., et al. (1993) "p. 28 Belongs to a Family of Epidermal Growth Factor-like Antigens That Are Targets of Malaria Transmission-blocking Antibodies", The Journal of Experimental Medicine, 177:505-519.
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Duffy Patrick E.
Kaslow David C.
Mosher Mary E.
The United States of America as represented by the Department of
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