Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-08-23
2011-08-23
Falk, Anne-Marie (Department: 1632)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C435S015000
Reexamination Certificate
active
08003315
ABSTRACT:
Human TAOJIK genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of TAOJIK are provided.
REFERENCES:
patent: 6165461 (2000-12-01), Cobb et al.
patent: 2003/0108937 (2003-06-01), Williamson
Houdebine (2000) Transgenic animal bioreactors. Transgenic Research. 9:305-320.
Kolb (1999) Insertion of a foriegn gene into the beta-casein locus by Cre-mediated site-specific recombination. Gene 227:21-31.
Vestraete (1999) Newer Throbolytic agents. Ann Acad. Med. Singapore; 28:424-33.
Sadick MD (1999) Kinase receptor activation (KIRA): a rapid and accurate alternative to endpoint bioassays. Developments in Biological Standardization 97: 121-133 (abstract only).
Hutchison,M., at al., “Homo sapiens thousand and one amino acid protein kinase (TA01), mRNA.”, Genbank GI No. 4759207 [online], Nov. 1, 2000 [retrieved Dec. 12, 2002]. Retrieved from the Internet<URL:http:/www.ncbi.nim.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nudeotide&list—uids=4759207&dopt=GenBank>.
Strausberg,R., “Homo sapiens, Similar to thousand and one amino acid protein kinase, clone Image:3878048, mRNA.”, Genbank GI No. 15929548 [online], Oct. 4, 2001 [retrieved Dec. 12, 2002]. Retrieved from the Internet:<URL:http:/www.ncbl.nlm,.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list—uids=15929548&dopt=GenBank>.
Moore, T.M., et al., “Homo sapiens prostate derived STE20-like kinase PSK (PSK), mRNA”, Genbank GI No. 7706400 [online], Nov. 5, 2002 [retrieved Dec. 12, 2002]. Retrieved from the Internet:<URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list—uids=7706400&dopt=GenBank>.
Tassi,E., et al., “Homo sapiens STE20-like kinase (JIK), mRNA.”, Genbank GI No. 7705559 [online], Nov. 2, 2000 [retrieved Dec. 12, 2002]. Retrieved from the Internet<URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nudeotide&list—uids=7705559&dopt=GenBank>.
NCBI Annotation Project., “Homo sapiens STE20-like kinase (JIK), mRNA.”, Genbank GI No. 20552662 [online], May 13, 2002 [retrieved Dec. 12, 2002]. Retrieved from the Internet<URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nudeotide&list—uids=20552662&dopt=GenBank>.
Strausberg,R., “Homo sapiens, STE20-like kinase, clone MGC:3364 Image:3630338.mRNA, complete cds.”, Genbank GI No. 12803830 [online], Jul. 12, 2001 [retrieved on Dec. 12, 2002]. Retrieved from the Internet<URL:http://www.ncbi.nlm.nih.gov/entrex/query.fcgi?cmd=Retrieve&db=nucleotide&list—uids.12803830&dopt=GenBank>.
Carter,T.G., et al., “Homo sapiens STE20-like kinase (JIK), mRNA.”, Genbank GI No. 19923463 [online], Apr. 4, 2002 [retrieved Dec. 12, 2002]. Retrieved from the Internet<URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list—uids=19923463&dopt.GenBank>.
NCBI Annotation Project., “Homo sapiens STE20-like kinase (JIK), mRNA.”, Genbank GI No. 15302531 [online], Feb. 7, 2002 [retrieved Dec. 12, 2002]. Retrieved from the Internet<URL:http://www.ncbi.nlm.nih.gov/entrez/query.lcgi?cmd=Retrieve&db=nucleotide&list—uids=15302531&dopt=GenBank>.
Nagase,T., el al., “Homo sapiens mRNA for KIAA1361 protein, partial cds.”, Genbank GI No. 7243102 [online], Mar. 14, 2000 [retrieved Dec. 12, 2002]. Retrieved from the Internet::<URL:http:www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list—uids.7243102&dopt=GenBank>.
NCBI Annotation Project., “Homo sapiens KIAA1361 protein (KIAA1361), mRNA.”, Genbank GI No. 18587661 [online], Feb. 7, 2002 [retrieved Dec. 12, 2002]. Retrieved from the Internet<URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nucleoticle&list—uids=18587661&dopt=GenBank>.
NCBI Annotation Project., “Homo sapiens KIAA1361 protein (KIAA1361), mRNA.”, Genbank GI No. 20559660 [online], May 13, 2002 [retrieved Dec. 12, 2002]. Retrieved from the Internet <URL:http:www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list—uids=20559660&dopt=GenBank>.
Yustein, J.T., et al., “Homo sapiensSTE20-like kinase mRNA, partial cds” Genbank GI No. 11596143 [online], Dec. 7, 2000 [retrieved Dec. 12, 2002]. Retrieved from the Internet:<URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list—uids=11596143&dopt=GenBank>.
Strausberg,R., “Homo sapiens, STE20-like kinase, clone MGC:3364 Image:3630338, mRNA, complete cds.” Genbank GI No. 12803830 [online], Jul. 12, 2001 [retrieved Dec. 12, 2002]. Retrieved from the Internet: <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list—uids=12803830&dopt.GenBank>.
Hutchison.M., el al.,“thousand and one amino acid protein kinase [Homo sapiens].” Genbank GI No. 4759208 [online]. Nov. 1, 2000 [retrieved Dec. 12, 2002]. Retrieved from the Internet<URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgl?cmd=Retrieve&db=protein&list—uids.4759208&dopt=GenPept>.
Tassi,E., et al., “STE20-like kinase: STE2-like kinase [Homo sapiens].”, Genbank GI No. 7705560 [online], Nov. 2, 2000 [retrieved Dec. 12, 2002]. Retrieved from the Internet<URL:http://www.ncbi.nlm.nlh.gov/entrez/query.fcgi?cmd?Retrieve&db=protein&list—uids.7705560&dopt=GenPept>.
Nagase,T., et al., “KIAA1361 protein [Homo sapiens]” Genbank GI No. 7243103 [online], Mar. 14, 2000 [retrieved Dec. 12, 2002]Retrieved from the Internet<URL:http://www.ncbi.nlm.nih.gov/entre/query.fcgi?cmd.Retrieve&db.protein&list—uids=7243103&dopt=GenPept>.
Williams Carol L et al.: “Reduced Expression of Wnt-1 and E-cadherin, and diminished beta-catenin stability in MCF-7 breast cancer cells that overexpress protein kinase C-alpha,” International Journal of Oncology, vol. 19, No. 6, Dec. 2001, pp. 1227-1233, XP002394272.
Zhang Yi et al.: “Axin forms a complex with MEKK1 and activates c-Jun NH2, terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling,” Journal of Biological Chemistry, vol. 274, No. 49, Dec. 3, 1999, pp. 35247-35254, XP002394562.
Sun T-Q et al.: “PAR-1 IA S Disheveled -Associated Kinase and a Positive Regulator of WNT Signaling,” Nature Cell Biology, Macmillan Publishers, GB, vol. 3, No. 7, Jul. 2001, pp. 628-636, XP008004678.
Feraldo Marisa M. et al.: “Growth defect induced by perturbation of beta-inttegrin function in the mammary gland epithelium result from a lack of MAPK activation via the Shc and Akt Pathways,” EMBO Reports, vol. 2, No. 5, May 2001, pp. 431-437, XP002394563.
Zhu B et al: “Inhibition of the Expression of Phosphodiesterase 5 by Antisense Inhibits the Growth of Human Colon Carcinoma (HT-29) Cells in Culture,” FASEB Journal (Federation of American Societies for Experimental Biology), Bethesda, US, vol. 15, No. 5, Mar. 8, 2001, p. A924.
Tao Weikang et al: “Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1” Genes and Development, vol. 15, No. 14, Jul. 15, 2001, pp. 1796-1807.
Depraetere V: PAR-1 Helps WNT to Get Rid 1-31 of JNK: Nature Cell Biology, Macmillan Publishers, GB, vol. 3, Jul. 2001, pp. E158-E159.
Elena Tassi et al.: “Human JIK, a Novel Member of the STE20 Kinase Family That Inhibits JNK and Is Negatively Regulated by Epidermal Growth Factor,” The Journal of Biological
Costa Michael A.
Dora, III Emery G.
Gendreau Steven Brian
Larson Jeffrey S.
Nicoll Monique
Exelixis Inc.
Falk Anne-Marie
McDonnell Boehnen & Hulbert & Berghoff LLP
LandOfFree
TAOJIKs as modifiers of the beta-catenin pathway and methods... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with TAOJIKs as modifiers of the beta-catenin pathway and methods..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and TAOJIKs as modifiers of the beta-catenin pathway and methods... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2747813