TAO protein kinase polypeptides and methods of use therefor

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

Reexamination Certificate

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C435S320100, C435S325000, C435S252300, C530S350000

Reexamination Certificate

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07078182

ABSTRACT:
Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.

REFERENCES:
patent: 6165461 (2000-12-01), Cobb et al.
patent: WO 99/02699 (1999-01-01), None
Database EMBL Accession No. AA234623, Mar. 6, 1997.
Database EMBL Accession No. AF068864, Sep. 23, 1998.
Allen et al., 1998, “PAK2 mutation in nonsyndromic X-linked mental retardation,”Nature Genetics 20:25-30.
Boulton et al., 1990, “An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle Control,”Science 249:64-67.
Burbelo et al., 1995, “A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases,”J. Biol. Chem. 270:29071-29074.
Courchesne et al., 1989, “A putative protein kinase overcomes pheromone-induced arrest of cell cycling inS. cerevisiae,” Cell 58:1107-1119.
Creasy and Chernoff, 1995, “Cloning and characterization of a member of the MST subfamily of Ste20-like kinases,”Gene 167:303-306.
Elion et al., 1990, “FUS3 encodes a cdc2+/CDC28-related kinase required for the transition for mitosis into conjugation”,Cell 60:649-664.
Hutchinson et al., 1998 “Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades,”J. Biol. Chem. 273:28625-28632.
Hunter and Plowman, 1997, “The protein kinases of budding yeast: six score and more”,Trends Biochem, Sci. 22:18-22.
Leberer et al., 1992, “The protein kinase homologue Ste20p is required to the link yeast pheromone response G-protein βγ submits to downstream signaling components”,EMBO J.11:4815-4824.
Marra et al., 1996 genban-est111 database, Accession No. g1541866.
Ramer and Davis, 1993, “A dominant truncation allele identifies a gene, STE20, that encodes a putative kinase necessary for mating inSaccharomyces cerevisiae”, Proc. Natl. Acad. Sci. USA 90:452-456.
Rhodes et al., 1990, “STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast,”Genes Dev. 4:1862-1874.
Robinson et al., 1996, “Contributions of the mitogen-activated protein (MAP) kinase backbone and phosphorylation loop to MEK specificity”,J. Biol. Chem. 271:29734-29739.
Su et al., 1997, “NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain”,EMBO J. 16:1279-1290.
Teague et al., 1986, “Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases”,Proc. Natl. Acad. Sci. USA 83:7371-7375.
Wu et al., 1995, “Molecular characterization of Ste20p, a potential mitogen-activated protein or extracelluar signal-regulated kinase kinase (MEK) kinase kinase fromSaccharonmyces cerevisiae,”, J. Biol. Chem. 270:15984-15992.

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