Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1992-12-21
1994-10-04
Kishore, G. S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424 59, 424401, 435174, 435175, 435177, 435182, A61K 9127
Patent
active
053524586
ABSTRACT:
A method for tanning skin is provided in which liposomes containing a DNA repair enzyme are administered to skin in combination with exposure of the skin to UV radiation. The result is an enhanced level of melanin production, i.e., more tanning than achieved by UV radiation alone. The administration of the DNA repair enzymes in liposomes also reduces the level of DNA damage caused by the UV exposure. Accordingly, both the tanning response is increased and the deleterious effect of UV exposure is decreased. The method can be used by the general population as well as by individuals whose skin is susceptible to UV-induced damage.
REFERENCES:
patent: 5077211 (1991-12-01), Yarosh
Kibitel et al. Photochem. & Photobid. 54 #5, 753, 1991.
Yarosh et al. J. Soc. Cosmet. Chem 41, 85, 1990.
Yarosh et al. Can. Res. 52, 4227, 1992.
Ceccoli et al., "Encapsulation of the UV-DNA Repair Enzyme T4 Endonuclease V in Liposomes and Delivery to Human Cells", J. Invest. Dermatol., vol. 93, pp. 190-194, Aug. 1989.
Kibitel et al., "Enhancement of Ultraviolet-DNA Repair in denV Gene Transfectants and T4 Endonuclease V-Liposome Recipients", Photochemistry and Photobiology, vol. 54, pp. 753-760, 1991.
Kripke et al., "Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice", Proc. Natl. Acad. Sci. U.S.A., vol. 89, pp. 7516-7520, Aug. 1992.
Yarosh et al., "Enhancement of DNA Repair of UV Damage in Mouse and Human Skin by Liposomes Containing a DNA Repair Enzyme", J. Soc. Cosmet. Chem., vol. 41, pp. 85-92, Jan./Feb. 1990.
Yarosh et al., "Pyrimidine Dimer Removal Enhanced by DNA Repair Liposomes Reduces the Incidence of UV Skin Cancer in Mice", Cancer Research, vol. 52, pp. 4227-4231, 1992.
Yarosh et al., "Effect of T4N5 Liposome-Enhanced DNA Repair on UV-Induced Transcription from the HIV Promoter", Abstract of the Proceedings of the 20th Annual Meeting of the American Society for Photobiology, Marco Island, Fla., Jun. 20-24, 1992, p. 80S.
Applied Genetics Inc.
Kishore G. S.
Klee Maurice M.
LandOfFree
Tanning method using DNA repair liposomes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tanning method using DNA repair liposomes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tanning method using DNA repair liposomes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-579987