Tandem time of flight mass spectrometer and method of use

Details Tandem time of flight mass spectrometer and method of use Tandem time of flight mass spectrometer and method of use

2007-03-27

2007-03-27

Nguyen, Kiet T. (Department: 2881)

Radiant energy

Ionic separation or analysis

Ion beam pulsing means with detector synchronizing means

Reexamination Certificate

active

10520871

ABSTRACT:
To provide comprehensive MS—MS analysis, a time-nested separation is employed using two time-of-flight (TOF) mass spectrometers. Parent ions are separated in a slow and long TOF1, operating at low ion energy (1 to 100eV), and fragment ions are mass analyzed in a fast and short TOF2, operating at much higher keV energy. A low energy fragmentation cell between TOF1and TOF2is tailored to accelerate fragmentation and dampening steps, mostly by shortening the cell and employing higher gas pressure. Slow separation in TOF1becomes possible with an introduction of novel TOF1analyzers. Higher performance is expected with the use of novel hybrid TOF1analyzers, combining radio frequency (RF) and quadratic DC fields. An RF field retains low-energy ions within a TOF1analyzer, while a quadratic DC field improves resolution by compensating for a large relative energy spread.

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