Radiant energy – Ionic separation or analysis – Ion beam pulsing means with detector synchronizing means
Patent
1991-05-16
1993-04-13
Hannaher, Constantine
Radiant energy
Ionic separation or analysis
Ion beam pulsing means with detector synchronizing means
250281, 250282, 250286, H01J 4940
Patent
active
052025632
ABSTRACT:
A tandem time-of-flight mass spectrometer comprises a grounded vacuum housing, two reflecting-type mass analyzers coupled via a collision chamber, and flight channels electrically floated with respect to the grounded vacuum housing. The first reflecting-type mass analyzer receives ionized molecules (ions). These ions pass through the flight channel of the first reflecting-type mass analyzer and are fragmented in the collision chamber. The fragmented ions pass through the flight channel of the second reflecting-type mass analyzer. Detectors disposed in the collision chamber and in the second reflecting-type mass analyzer detect the spectrum of the first reflecting-type mass analyzer and the spectra of the tandem time-of-flight mass analyzer, respectively.
REFERENCES:
patent: 4694168 (1987-09-01), Le Beyec et al.
patent: 4731532 (1988-03-01), Frey et al.
patent: 4851669 (1989-07-01), Aberth
patent: 5032722 (1991-07-01), Boesl et al.
patent: 5065018 (1991-11-01), Bechtold et al.
patent: 5117107 (1992-05-01), Guilhaus et al.
W. C. Wiley, I. H. McLaren, Time-of-Flight Mass Spectrometer with Improved Resolution, The Review of Scientific Instruction, vol. 26, No. 12, Dec. 1955, pp. 1150-1157.
M. L. Muga, Effectiveness of Velocity Compaction Focusing for Improving the Resolving Power . . . , 35th Conf. on Mass Spectrometry and Allied Topics, May 1987, pp. 1126-1127.
F. Knorr, D. Chatfield, Fourier Transform Time of Flight Mass Spectrometry, Dept. of Chemistry, pp. 719-722.
R. Van Breemen, M. Snow, R. Cotter, Time-Resolved Laser Desorption Mass Spectrometry, Inter. Journal of Mass Spectrometry and Ion Physics, 49 (1983) 35-50.
J.-Claude Tabet, R. Cotter, Laser Desorption Time-of-Flight Mass Spectrometry of High Mass Molecules, American Chemical Society, 1984, 56, 1662-1667.
J. Olthoff, I. Lys, P. Demirev, R. Cotter, Modification of Wiley-McLaren TOF Analyzers for Laser Desoprtion, Analytical Instrumentation, 16(1), 93-115 (1987).
J. Olthoff, J. Honovich, R. Cotter, Liquid Secondary Ion Time-of-Flight Mass Spectrometry, American Chemical Society, 1987, 59, 999-1002.
J. Olthoff, R. Cotter, Liquid Secondary Ion Mass Spectrometry, Nuclear Instruments and Methods in Physics Res., B26, 1987, pp. 566-570.
D. Torgerson, R. Skowronski, R. Macfarlane, New Approach to the Mass Spectroscopy of Non-Volatile Compounds, Biochem. and Biophys. Research Comm., vol. 60, No. 2, 1974, pp. 616-621.
B. Chait, F. Field, 252Cf Fission Fragment Ionization Mass Spectrometry of Chlorophyll a, J. Amer. Chem. Soc., 1984, 106, 1931-1938.
Y. Beyec, S. Della Negra, C. Deprun, P. Vigny, Y. Ginot, Mass Determination of Molecules of Biological Interest by Fast Heavy Ions Induced . . . , Revue Phys. Appl. 15 (1980) 1631-1637.
A. Viari, Jean-Pierre Ballini, P. Vigny, Sequence Analysis of Unprotected Tri-Deoxyribonucleoside Diphosphates by . . . , Biomed. & Envir. Mass Spec., vol. 14, pp. 83-90 (1987).
P. Hakansson, B. Sundqvist, The Velocity Dependence of Fast Heavy-Ion Induced Desorption of Biomolecules, Radiation Effects, 1982, vol. 61, pp. 179-193.
O. Becker, N. Furstenau, F. Krueger, G. Weib, K. Wien, Ionization of Non-Volatile Organic Compounds by Fast Heavy Ions and Their Separation by . . . , Nuclear Instruments and Methods, 139, (1976), 195-201.
B. Chait, K. Standing, A Time-of-Flight Mass Spectrometer for Measurement of Secondary Ion Mass Spectra, Inter. Journal of Mass Spectrometry and Ion Physics, 40 (1981) 185-193.
K. Tanaka, H. Waki, Y. Ido, S. Akita, Y. Yoshida, T. Yoshida, Protein and Polymer Analyses Up to m/z 100000 by Lazer Ionization Time-of-Flight Mass, Rapid Comm. in Mass Spec., vol. 2, No. 8, 1988, pp. 151-153.
M. Karas, F. Hillenkamp, Laser Desorption Ionization of Proteins with Molecular Masses Exceeding 10000 Daltons, Analytical Chemistry, vol. 60, No. 20, Oct. 15, 1988, pp. 2299-2301.
R. Beavis, B. Chait, Factors Affecting the Ultraviolet Laser Desorption of Proteins, Rapid Comm. in Mass Spectrometry, vol. 3, No. 7, 1989, pp. 233-237.
B. Mamyrin, V. Karataev, D. Shmikk, V. Zagulin, The Mass-Reflection, A New Nonmagnetic Time-of-Flight Mass Spectrometer with High Resolution, Sov. Phys. JETP, vol. 37, No. 1, Jul. 1973, pp. 45-48.
R. Kaufmann, R. Nitsche, A High-Sensitivity Laser Mic
The invention disclosed herein was supported at least in part by funds received from the National Institutes of Health under Grant No. NIH: R01 GM-33967. Accordingly, the Government may have certain rights in this invention.
Cornish Timothy J.
Cotter Robert J.
Beyer James
Hannaher Constantine
The Johns Hopkins University
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