Tandem synthetic HIV-1 peptides

Details Tandem synthetic HIV-1 peptides Tandem synthetic HIV-1 peptides

1994-06-09

1997-06-17

Smith, Lynette F.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 4242081, 4242041, A61K 3800, A61K 3912, A61K 3921, C07K 500

Patent

active

056398549

ABSTRACT:
Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.

REFERENCES:
patent: 5229490 (1993-07-01), Tam
Sia et al, "Construction of Immunogenic Synthetic HIV Vaccine Candidates"; Proceedings of the International Conference of AIDS, Rome, IT, 1992; see Abstract M.A.68.
Sia et al, "Construction of Synthetic HIV Vaccine Candidates"; Final Program and Oral Abstracts, vol. 8, No. 1, Abstract No. WeD 1039; VIII International Conference of AIDS/III STD World Congress, Amsterdam, The Netherlands, 19-24 Jul. 1992.
Luo et al, "Chimeric gag-V3 virus-like particles of human immunodeficiency virus induce virus-neutralizing antibodies" Proc. Natl. Acid. Sci. US A, vol. 89, pp. 10527-10531--Nov. 1992.
Tam, J.P., "Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system"; Proc. Natl. Acad. Sci. USA, vol. 85, pp. 5409-5414, Aug. 1988.
Webster's Ninth New Collegiate Dictionary, 1990, p. 602.
Cohen, 1993, "Jitters Jeopardize AIDS Vaccine Trials" Science 262: 980-981.
Sia, et al, 1991, "Structure and Immunogenicity of . . . " Sixieme Colloque Des Cent Gardes, pp. 105-110.
Chong, et al, 1990, "Identification of a potent . . . " FEBS Letters 264(2): 231-234.

Affiliated with

Also associated with

Rating

Tandem synthetic HIV-1 peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tandem synthetic HIV-1 peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tandem synthetic HIV-1 peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2158725