Tandem synthetic HIV-1 peptides

Details Tandem synthetic HIV-1 peptides Tandem synthetic HIV-1 peptides

1995-06-02

1998-06-02

Smith, Lynette F.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 71, 4242081, A61K 3921, C12Q 170, G01N 3353, G01N 33567

Patent

active

057597693

ABSTRACT:
Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.

REFERENCES:
Sia et al, "Construction of Immunogenic Synthetic HIV Vaccine Candidates"; Proceedings of the International Conference on AIDS, Rome, IT, 1992, see Abstract, M.A. 68.
Sia et al, "Construction of Synthetic HIV Vaccine Candidates"; Final Program and Oral Abstracts, vol. 8, No. 1, Abstract No. WeD1039; VIII International Conference on AIDS/III STD World Congress, Amsterdam, the Netherlands, 19-24 Jul. 1992.
Luo et al, "Chimeric gag-V3 virus-like particles of human immunodeficiency virus induce virus-neutralizing antibodies" Proc. Natl. Acad. Sci. USA, vol. 89, pp. 10527-10531--Nov. 1992.
Tam, J.P. "Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system"; Proc. Natl. Acad. Sci. USA, vol. 85, pp. 5409-5414, Aug. 1988.
Nick et al. "Identification of HIV-1 env and gag Immunogenic Epitopes Using Sequence-Homologous Synthesis Peptides" AIDS-Forschung 6 (9): 467-473 (1991).
Shoeman et al. "Comparison of Recombinant Human Immunodeficiency Virus gag Precursor and gag/env Fusion Proteins and a Synthetic env Peptide as Diagnostic Reagents" Anal. Bioch. 161, 370-379 (1987).
Kenealy et al: "Analysis of Human Serum Antibodies to Human Immunodeficiency Virus (HIV) Using Recombinant ENV and GAG antigens" AIDS Res. and Human Retrov., vol. 3, No. 1:95-105 (1987).
Cohen: Jitters Jeopardize AIDS Vaccine Trials, Science, vol. 262, pp. 980-981 (Nov. 1993).
Norley et al: "Vaccination against HIV", Immunol., vol. 184, pp. 193-207 (1992).
Palker et al: "Polyvalent Human Immunodeficiency Virus Synthetic Immunogen comprised of Envelope gp120 T Helper Cell Sites and B Cell Neutralization Epitopes" J. of Immunology, vol. 142, No. 10:3612-3619 (1989).
Spalding, B. J. Biotechnology 10: 24-29, 1992.
Pasidero, L. P., Sheu, M. and Ruscetti, F. W. J. Virol. 63: 267-272, 1988.
Sarin, P. S., Sun, D. K., Thornton, A. H. Naylor, P. H. and Goldstein, A. L. Science 232: 1135-1137, 1986.
Palker, T. J. et al., J. of Immunol. 142: 3612-3619, 1989.
Gorny, M. K., Xu, J-Y., Gianakakos, V., Karkowska, S., Williams, C., Sheppard, H. W., Hanson, C. V. and Zolla-Pasner, S. Proc. Natl. Acad. Sci., USA, 88: 3238-3242, 1991.
Buchacher, A. et al, AIDS Research and Human Retroviruses, 10: 359-369, 1994.
Skinner, M. A., Langlois, A. J., Mcdanal, C. B. McDougal, J. S., Bolognesi, D. and Mathews, T. J. J. Virol. 62; 4195-4200, 1988.
Tam, J. P. Proc. Natl. Acad. Sci., USA 85: 5409-5413, 1988.
Sondergard-Andersen, J. et al. Journal of Immunological Methods 131: 99-104, 1990.
O'Hagan (1992), Clin. Pharmokinet 22:1.
Ulmer et al (1993), Curr. Opinion Invest. Drugs 2(9):983-989.

Affiliated with

Also associated with

Rating

Tandem synthetic HIV-1 peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tandem synthetic HIV-1 peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tandem synthetic HIV-1 peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1458205