Tandem synthetic HIV-1 peptides

Details Tandem synthetic HIV-1 peptides Tandem synthetic HIV-1 peptides

1995-06-05

1998-09-01

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242041, 4241841, 4241881, 530350, 530324, 530327, A61K 3921, A61K 3900, C07K 500, C07K 700

Patent

active

058008225

ABSTRACT:
Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.

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