Tandem synthetic HIV-1 peptide

Details Tandem synthetic HIV-1 peptide Tandem synthetic HIV-1 peptide

1995-06-05

1998-10-06

Smith, Lynette F.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530326, 530327, 530325, 530350, 4241881, 4241841, 4242081, 4242041, A61K 3800, A61K 3921, C07K 500, C07K 1700

Patent

active

058177540

ABSTRACT:
Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.

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