Tandem mass spectrometry method

Details Tandem mass spectrometry method Tandem mass spectrometry method

2005-08-02

2005-08-02

Nguyen, Kiet T. (Department: 2881)

Radiant energy

Ionic separation or analysis

Methods

C250S292000, C250S296000

Reexamination Certificate

active

06924478

ABSTRACT:
Multiply charged ions are trapped and accumulated in a spatially limited region before being injected into an ion trap mass spectrometer such as a Fourier transform ion cyclotron resonance mass spectrometer (FTICR MS). In the ion trap electron capture dissociation (ECD) and vibrational excitation dissociation are sequentially applied on ions of the same ion ensemble. The first dissociation process does not fragment all primary ions. Following the detection of the dissociation products, the primary ions that remain undissociated undergo the vibrational excitation and again, a part of them dissociate, and the fragments are detected. Thus, the same ion ensemble is used for two fragmentation processes. During these processes, further ions generated in the external ion source are accumulated in the spatially limited region for subsequent analyses.

REFERENCES:
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