Tandem asymmetric transformation process

Details Tandem asymmetric transformation process Tandem asymmetric transformation process

1997-11-12

1999-11-02

Nazario-Gonzalez, Porfirio

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548108, 549212, 556122, 556135, 564165, 564191, 564197, C07F 306, C07C23300, C07C23500

Patent

active

059773715

ABSTRACT:
The instant invention provides a homologation process for making a zincate homoenolate from a carbon bound enolate zincate, by treating the carbon bound enolate zincate with an alkoxy lithium reagent. The homologation step can be coupled with a homoaldol reaction, as well as with other transmetallation reactions, in a one pot process. The zincate homoenolate is a useful intermediate in the preparation of a variety of different end-products, such as HIV protease inhibitors and renin inhibitors.

REFERENCES:
patent: 5587514 (1996-12-01), Liotta et al.
patent: 5643878 (1997-07-01), Bold et al.
patent: 5663168 (1997-09-01), Rosel et al.
patent: 5703092 (1997-12-01), Xue et al.

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