Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Reexamination Certificate
2011-04-19
2011-04-19
Yang, N. C. (Department: 1641)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
C424S009322, C424S009340, C435S004000, C435S007100
Reexamination Certificate
active
07927579
ABSTRACT:
The present invention provides methods of discovering and mapping secondary binding sites on biological molecules (e.g., proteins), the effects, if any, of site occupancy on the primary function of the molecule, and the screening of small molecules against the secondary binding sites. The invention further provides novel complexes for modification of secondary binding sites and the resulting modified biological molecules.
REFERENCES:
patent: 5840733 (1998-11-01), Krantz et al.
patent: 5942620 (1999-08-01), Krantz et al.
patent: 6013792 (2000-01-01), Castelhano et al.
patent: 6107489 (2000-08-01), Krantz et al.
patent: 6277583 (2001-08-01), Krantz et al.
patent: 6277863 (2001-08-01), Krantz et al.
patent: 6303569 (2001-10-01), Greenwald et al.
patent: 6335155 (2002-01-01), Wells et al.
patent: 6403324 (2002-06-01), Krantz et al.
patent: 6936597 (2005-08-01), Greenwald et al.
patent: 2002/0064799 (2002-05-01), Cravatt et al.
patent: 2005/0037974 (2005-02-01), Krantz et al.
patent: 1056474 (2002-06-01), None
patent: 0956049 (2002-10-01), None
patent: WO-97/25074 (1997-07-01), None
patent: WO-97/29372 (1997-08-01), None
patent: WO-98/00171 (1998-01-01), None
patent: WO-99/24075 (1999-05-01), None
patent: WO-99/24076 (1999-05-01), None
patent: WO-99/24462 (1999-05-01), None
patent: WO-02/063271 (2002-08-01), None
Birkenmeier, G. & Kopperschlager, G. Detection of conformational changes in proteins by probing with poly(ethylene glycol)-bound ligands. Methods Enzymol. 1994;228:264-275.
Ingham, K.C. Protein precipitation with polyethylene glycol. Methods Enzymol. 1984;104:351-356.
Johansson, G. Affinity partitioning. Methods Enzymol. 1984;104:356-364.
International Search Report and Written Opinion from WO 04/066917.
Database Biosis Accession No. PREV198018031914, (1979).
Evans, Bettie et al., “Inactivation of Cathepsin B by Active Site-directed Disulfide Exchange, Application in Covalent Affinity Chromatography,”The Journal of Biological Chemistry, vol. 258(17):10227-10232 (1983).
Leelasvatanakij, L. et al., “A solid-phase synthetic strategy for the preparation of peptide-based affinity labels: synthesis of dynorphin A analogs,”J. Peptide Res., vol. 56:80-87 (2000).
Powers, Stephen P. et al., “Use of Photoaffinity Probes Containing Poly(ethylene glycol) Spacers for Topographical Mapping of the Cholecystokinin Receptor Complex,”Biochemistry, vol. 30:676-682 (1991).
Ruppert, Jim et al., “Automatic identification and representation of protein binding sites for molecular docking,”Protein Science, vol. 6:524-533 (1997).
Smith, Geoffrey B. et al., “Functional domains of GABAAreceptors,”Trends in Pharmacological Sciences, vol. 16(5):162-168 (1995).
European Office Action for Application No. 04702918.6, dated Apr. 1, 2008.
Advanced Proteome Therapeutics, Inc
Nelson Mullins Riley & Scarborough LLP
Trinque Brian C.
Yang N. C.
LandOfFree
Tandem analyses of noncovalently driven effectors for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tandem analyses of noncovalently driven effectors for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tandem analyses of noncovalently driven effectors for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2651819