TAN-1511, its derivatives, production and use thereof

Details TAN-1511, its derivatives, production and use thereof TAN-1511, its derivatives, production and use thereof

1993-12-28

1995-12-26

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514 18, 530329, 530330, 530331, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

054788099

ABSTRACT:
A compound of the formula: ##STR1## wherein each R.sup.1, R.sup.2 and R.sup.3 is an aliphatic acyl group, X is an amino acid sequence consisting of 1 to 5 amino acid residues which contain at least one acidic amino acid residue, n is an integer of 0 to 4, provided that when n is 0, X has glutamyl-glycyl at its N-terminal and when n is 1 or 2, the acidic amino acid residue is an acidic amino acid residue other than D-glutamyl, or a salt thereof has an activity of remarkably improving anhematopoiesis and is useful as an immuno-stimulating agent having a leukocyte-increasing activity.

REFERENCES:
patent: 4666886 (1987-05-01), Baschang et al.
Chem. Pharm. Bull., "Synthesis of Optically Active Lipopeptide Analogs from the Outer Membrane of Escherichia coli" Kurimura et al., 39 (10), pp. 2590-2596 (1991).
Chem. Pharm. Bull., "Synthesis and Mitogenic Activity of Chiral Lipopeptide WS1279 and Its Derivatives" Kurimura et al., 41(11), pp. 1965-1970 (1993).
Chem. Pharm. Bull., "Synthesis of Biologically Active Pentapeptide Analogs of the N-Terminal Part of Lipoprotein From the Outer Membrane of Escherichia coli" Kurimura et al., 38 (4), pp. 1110-1112 (1990).
Peptide Chemistry 1990: Y. Shimonishi (Ed.), Protein Research Foundation, Osaka, Japan (1990), "Synthesis and Mitogenic Activity of Lipopeptide and Its Analogs" Kurimura et al., pp. 37-42.
Peptide Chemistry 1991: A. Suzuki (Ed.) Protein Research Foundation, Osaka, Japan (1991), "Stereospecific Synthesis and Mitogenic Activity of Lipopeptide WS 1279 and Its Derivatives" Kurimura et al., pp. 361-366.
Int. J. Peptide Protein Res., "Synthesis of Novel Immunologically Active Tripalmitoyl-S-Glycerylcysteinyl Lipopeptides as Useful Intermediates for Immunogen Preparations" Metzger et al., 37, 1991, pp. 46-57.

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