Tamsulosin derivative

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S603000

Reexamination Certificate

active

07084301

ABSTRACT:
The optically active compound, R (−)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-hydroxybenzenesulfonamide in good optical purity, a metabolite of the α1-adrenergic blocking agent tamsulosin, and methods for the preparation thereof. Pharmaceutical compositions including the optically active compound and methods of treatment comprising administration of an effective α1-adrenergic antagonistic amount of such compositions to mammals.

REFERENCES:
patent: 4703063 (1987-10-01), Imai et al.
patent: 4731478 (1988-03-01), Niigata et al.
patent: 5391825 (1995-02-01), Niigata et al.
patent: 1282077 (1991-03-01), None
Taguchi et al., “Effects of Tamsulosin Metabolites in Alpha-1 Adrenoceptor Subtypes”,The Journal of Pharmacology and Experimental Therapeutics, 280(1):1-5 (1997).
Soeishi et al., “Metabolism of tamsulosin in rat and dog”,Xenobiotica, 26(3):355-365 (1996).
Soeishi et al., “Absorption, metabolism and excretion of tamsulosin hydrochloride in man”,Xenobiotica, 26(6):637-645 (1996).
Wheeler et al., “The Synthesis of the14C and2H-Isotopomers of (R)-N-[2-(2′-Ethoxyphenoxy)-Ethyl]-N-2-[3-(4′-Methoxy-3′-Sulfonamido)-Phenyl]-Propylamine Hydrochloride, an α1-Adrenoreceptor Antagonist1”,Journal of Labelled Compounds and Radiopharmaceuticals, 27(2):171-180 (1989).
Vatz, “Alpha1-Adrenergic Blockers: Do They Have a Place in the Prophylaxis of Migraine?”,Headache, 37:107-108 (1997).
Kuo et al., “Design, Synthesis, and Structure-Activity Relationships of Phthalimide-Phenylpiperazines: A Novel Series of Potent and Selective α1a-Adrenergic Receptor Antagonists”,Journal of Medicinal Chemistry, 43:2183-2195 (2000).
Lee et al., “Cardiovascular Activity of A-74283, a 5-Hydroxytryptamine1aAgent, in the Spontaneously Hypertensive Rat”,Pharmacology, 56(1):17-29 (1998).
Schiffrin et al., “Platelet binding sites and plasma concetration of atrial natriuretic peptide in patients with essential hypertension”,Journal of Hypertension, 6(7):565-572 (1988).
Dando et al., “Modulation of the vagal bradycardia evoked by stimulation of upper airway receptors by central 5-HT1receptors in anaesthetized rabbits”,British Journal of Pharmacology, 125:409-417 (1998).
Phillips et al., “The effects of the novel anxiolytic drug lesopitron, a full and selective 5-HT1areceptor agonist, on pupil diameter and oral temperature in man: comparison with buspirone”,Journal of Psychopharmacology, 13(4):391-397 (1999).
Testa et al., “Effect of Several 5-Hydroxytryptamine1AReceptor Ligands on the Micturition Reflex in Rats: Comparison with WAY 1006351”,The Journal of Pharmacology and Experimental Therapeutics, 290(3):1258-1269 (1999).
Jose et al., “Role of dopamine receptors in the kidney in the regulation of blood pressure”,Current Opinion in Nephrology and Hypertension, 11(1):87-92 (2002).
Mühlbauer et al., “Dopamine D3receptors in the rat kidney: role in physiology and pathophysiology”Acta Physiologica Scandinavica, 168(1):219-223 (2000).
Velasco et al., “Dopaminergic receptors: a new antihypertensive mechanism”,Journal of Hypertension, 20(S3):S55-S58 (2002).
Amenta et al., “The Dopaminergic System in Hypertension”,Clinical and Experimental Hypertension, 23(1&2):15-24 (2001).
Keffel et al., “α1-Adrenoceptor Subtypes Differentially Couple to Growth Promotion and Inhibition in Chinese Hamster Ovary Cells”,Biochemical and Biophysical Research Communications, 272:906-911 (2000).
Michel et al., “Identification of a single α1-adrenoceptor corresponding to the α1A-subtype in rat submaxillary gland”,British Journal of Pharmacology, 98:883-889 (1989).
Cheng & Prusoff, “Relationship Between the Inhibition Constant (Kl) and the Concentration of Inhibitor Which Causes 50 Per Cent Inhibition (I50) of an Enzymatic Reaction”,Biochemical Pharmacology, 22:3099-3108 (1973).
Martin et al., “Classification Review. Receptors for 5-Hydroxytryptamine: Current Perspectives on Classification and Nomenclature”,Neuropharmacology, 33(3/4):261-273 (1994).
Sokoloff et al., “Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics”,Nature, 347:146-151 (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Tamsulosin derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tamsulosin derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tamsulosin derivative will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3634426

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.