Tamoxifen as a therapy to reduce irinotecan hydrochloride-induce

Details Tamoxifen as a therapy to reduce irinotecan hydrochloride-induce Tamoxifen as a therapy to reduce irinotecan hydrochloride-induce

1998-02-24

1999-09-21

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514651, A61K 3144, A61K 31135

Patent

active

059554665

ABSTRACT:
The present invention provides a method for preventing or decreasing diarrhea associated with irinotecan administration comprising the administration of tamoxifen at least two cell cycles prior to irinotecan administration.

REFERENCES:
Jaiyesimi, IA, et al.; J. Clin. Oncol. 13:513-529, 1995.
Gould, K, et al.; Oncol. Nurs. Forum. 21:835-840, 1994.
Otto, AM, et al.; J. Cancer Res. Clin. Oncol. 122:603-612, 1996.
Watts, CKW, et al.; Mol. Endocrin. 9:1804-1813, 1995.

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