Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-05-17
2011-05-17
Cook, Lisa V (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C436S001000, C436S501000, C436S518000, C424S009100, C424S520000, C422S001000, C422S050000, C530S300000, C530S350000
Reexamination Certificate
active
07943330
ABSTRACT:
The present disclosure relates to tailored glycoproteomic methods, and more particularly to methods for the sequencing, mapping and identification of cellular glycoproteins using saccharide-selective bioorthogonal probes. A method is disclosed for saccharide-selective glycoprotein identification (ID) and glycan mapping (GIDmap) that generates glycoproteins tailored with bioorthogonally tagged alkynyl saccharides that can be selectively isolated, allowing for glycoprotein ID and glycan mapping via mass spectromic proteomics, including liquid chromatography-tandmen mass spectroscopy (LC-MS2). LC-MS2may be used to identify cellular glycans, and more specifically cancer-related glycoproteins.
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Prescher, J. A.
Hanson Sarah R
Hsu Tsui-Ling
Wong Chi-Huey
Academia Sinica
Cook Lisa V
Eckman Basu LLP
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