Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Reexamination Certificate
2006-09-15
2008-10-07
Witherspoon, Sikarl A. (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
C514S718000, C568S377000, C568S731000, C552S293000, C552S309000
Reexamination Certificate
active
07432305
ABSTRACT:
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed.
REFERENCES:
patent: 2398418 (1946-04-01), Fieser
patent: 2856414 (1958-10-01), Robeson et al.
patent: 3071512 (1963-01-01), Feldmann
patent: 3406188 (1968-10-01), Fletcher
patent: 3705239 (1972-12-01), Gregory
patent: 3849453 (1974-11-01), Morrimoto et al.
patent: 3896153 (1975-07-01), Sato et al.
patent: 3909376 (1975-09-01), Degner
patent: 3957836 (1976-05-01), Morimoto et al.
patent: 4127608 (1978-11-01), Olson et al.
patent: 4153614 (1979-05-01), Barner et al.
patent: 4185154 (1980-01-01), Olson et al.
patent: 4201726 (1980-05-01), Olson et al.
patent: 4201879 (1980-05-01), Barner et al.
patent: 4234490 (1980-11-01), Barner et al.
patent: 4243598 (1981-01-01), Olson et al.
patent: 4310465 (1982-01-01), Olson et al.
patent: 4388312 (1983-06-01), Terao et al.
patent: 4393075 (1983-07-01), Terao et al.
patent: 4436753 (1984-03-01), Imada et al.
patent: 4491594 (1985-01-01), Ogawa et al.
patent: 4495104 (1985-01-01), Imada et al.
patent: 4559177 (1985-12-01), Okutani et al.
patent: 4592867 (1986-06-01), Yu et al.
patent: 4599232 (1986-07-01), Bertelli
patent: 4694090 (1987-09-01), Shiono et al.
patent: 4814346 (1989-03-01), Albert et al.
patent: 4818441 (1989-04-01), Imada et al.
patent: 4831265 (1989-05-01), Watanabe et al.
patent: 5057514 (1991-10-01), Tatsuoka et al.
patent: 5059627 (1991-10-01), Goto et al.
patent: 5179092 (1993-01-01), Tatsuoka et al.
patent: 5180742 (1993-01-01), Terao et al.
patent: 5210239 (1993-05-01), Abe et al.
patent: 5229385 (1993-07-01), Terao et al.
patent: 5288752 (1994-02-01), Tatsuoka et al.
patent: 5292768 (1994-03-01), Tatsuoka et al.
patent: 5304658 (1994-04-01), Terao et al.
patent: 5547827 (1996-08-01), Chen et al.
patent: 5600029 (1997-02-01), Kaneko et al.
patent: 5846988 (1998-12-01), Hellberg
patent: 5969133 (1999-10-01), Ono et al.
patent: 5981601 (1999-11-01), Nagley et al.
patent: 6011046 (2000-01-01), Ohkawa et al.
patent: 6045826 (2000-04-01), Borowy-Borowski et al.
patent: 6083982 (2000-07-01), Wechter et al.
patent: 6133278 (2000-10-01), Terao et al.
patent: 6133322 (2000-10-01), Rustin et al.
patent: 6136859 (2000-10-01), Henriksen
patent: 6150402 (2000-11-01), Wechter et al.
patent: 6271266 (2001-08-01), Miyamoto et al.
patent: 6300377 (2001-10-01), Chopra
patent: 6331532 (2001-12-01), Murphy et al.
patent: 6342516 (2002-01-01), Umeda et al.
patent: 6417233 (2002-07-01), Sears et al.
patent: 6426362 (2002-07-01), Miller et al.
patent: 6433199 (2002-08-01), Ono et al.
patent: 6454184 (2002-09-01), Merkel et al.
patent: 6740338 (2004-05-01), Chopra
patent: 6764768 (2004-07-01), Mrksich et al.
patent: 6852895 (2005-02-01), Lipshutz et al.
patent: 6977270 (2005-12-01), Baldenius et al.
patent: 2002/0182196 (2002-12-01), McCleary
patent: 2003/0119054 (2003-06-01), Mrksich et al.
patent: 2004/0043103 (2004-03-01), McCLeary
patent: 2004/0156871 (2004-08-01), Borowy-Borowski et al.
patent: 2005/0043553 (2005-02-01), Smith et al.
patent: 2005/0065099 (2005-03-01), Walkinshaw et al.
patent: 2005/0065150 (2005-03-01), Wang et al.
patent: 2005/0186518 (2005-08-01), Masskasky et eal.
patent: 2005/0222218 (2005-10-01), Meier et al.
patent: 2006/0002885 (2006-01-01), Mielke et al.
patent: 2006/0281809 (2006-12-01), Miller et al.
patent: 38 18 696 (1989-03-01), None
patent: 0 134 198 (1985-03-01), None
patent: 0 619 313 (1994-10-01), None
patent: 0 719 552 (1995-12-01), None
patent: 0 719 552 (1995-12-01), None
patent: 1 378 753 (2004-01-01), None
patent: 1 378 753 (2004-01-01), None
patent: 1.201.200 (1959-12-01), None
patent: 75.631 (1961-06-01), None
patent: 5.531 (1967-12-01), None
patent: 1.536.576 (1968-08-01), None
patent: 40-9029 (1965-05-01), None
patent: 56-140943 (1981-11-01), None
patent: 57-050935 (1982-03-01), None
patent: 58-083698 (1983-05-01), None
patent: 58-193689 (1983-11-01), None
patent: 60-28919 (1985-02-01), None
patent: 61-040236 (1986-02-01), None
patent: 1-093554 (1989-04-01), None
patent: 1 209445 (1989-08-01), None
patent: 5-11467 (1993-01-01), None
patent: 8-92151 (1996-04-01), None
patent: 2000-202297 (2000-07-01), None
patent: 2003-64017 (2003-03-01), None
patent: 2003-137716 (2003-05-01), None
patent: WO-93/24650 (1993-12-01), None
patent: WO-98/34646 (1998-08-01), None
patent: WO-00/50043 (2000-08-01), None
patent: WO-01/52822 (2001-07-01), None
patent: WO-01/92215 (2001-12-01), None
patent: WO-01/92215 (2001-12-01), None
patent: WO-02/34259 (2002-05-01), None
patent: WO-02/067864 (2002-09-01), None
patent: WO-02/067864 (2002-09-01), None
patent: WO-2004/003565 (2004-01-01), None
patent: WO-2004/003565 (2004-01-01), None
patent: WO-2004/042353 (2004-05-01), None
patent: WO-2004/042353 (2004-05-01), None
patent: WO-2005/000357 (2005-01-01), None
patent: WO-2005/000357 (2005-01-01), None
patent: WO-2005/019232 (2005-03-01), None
patent: WO-2005/033092 (2005-04-01), None
patent: WO-2005/033093 (2005-04-01), None
patent: WO-2005032544 (2005-04-01), None
patent: WO-2005/105159 (2005-11-01), None
patent: WO-2005/105159 (2005-11-01), None
patent: WO-2006/130775 (2006-12-01), None
patent: WO-2006/130775 (2006-12-01), None
patent: WO-2007/035496 (2007-03-01), None
patent: WO-2007/095630 (2007-08-01), None
patent: WO-2007/095630 (2007-08-01), None
Cressman et al. One-Step Synthesis of Polyalkyl-2-iodo-p-benzoquinones. Journal of Organic Chemistry, 1966, 31 (4), p. 1279-1281.
Shi et al. Hydrophobic Acceleration of Electron Transfer Processes. Journal of Organic Chemistry, 1996, vol. 61, p. 4698-4702.
Gu et al. Synthesis and Inhibitory Activity of Bromoquinone Derivatives. Tetrahedron, 1990, 46 (9), pp. 3199-3210.
Adelwöhrer, C. et al. (2005, e-pub. Aug. 2, 2005). “Novel Tocopheryl Compounds XX. 1,3,8-Trioxaphenanthrenes Derived from γ-Tocopherol,”Tetrahedron61:9070-9074.
Armstrong, J.S. et al. (Dec. 5, 2003). “The Coenzyme Q10Analog Decylubiquinone Inhibits the Redox-Actived Mitochondrial Permeability Transition,”The Journal of Biological Chemistry278(49):49079-49084.
Asgill, J.O. et al. (Jan. 4, 1978). “Chromenylation of 2-Napthol and Alkylhydroquinones: Short Synthesis of (2RS,4′R, 8′R)-α-Tocopherol (Vitamin E) and (2RS,4′R, 8′R)-β-Tocopherol,”The Journal of The Chemical Society Chemical Communications1:59-60.
Boyer, P.D. (Feb. 19, 1951). “The Preparation of Reversible Oxidation Product of α-Tocopherol, α-Tocopheroxide and of Related Oxides,”Journal of the American Chemical Society73(2):733-740.
Briere, J-J. et al. (Apr. 16, 2004). “Wuinone Analogues Regulate Mitochondrial Substrate Competitive Oxidation,”Biochemical and Biophysical Research Communications316(4):1138-1142.
Calviello, G. et al. (2003). “γ-Tocopheryl Wuinone Inducs Apoptosis in Cancer Cells Via Caspase-9 Activation and CytochromecRelease,”Carcinogenesis24(3):427-433.
Caplus Accession No. 1967:18647, created May 12, 1984, 9 pages.
Caplus Accession No. 1969:433438, created May 12, 1984, 1 page.
Caplus Accession No. 169:524242, created May 12, 1984, 3 pages.
Caplus Accession No. 1989:553350, created Oct. 28, 1999, 4 pages.
Caplus Accession No. 2003:166979, created Mar. 5, 2003, 5 pages.
Caplus Accession No. 2003:487787, created Jun. 27, 2003, 8 pages.
Cohen, N. et al. (1981). “Studies on the Total Synthesis of (2R,4′R,8′R)-α-Tocopherol (Vitamin E). Stereospecific Cyclizations Leading to Optically Active Chromans,”The Journal of Organic Chemistry46(12):2445-2450.
Dowd, P. et al. (Aug. 1995). “On the Mechanism of the Anticlotting Action of Vitamin E Quinone,”Proceedings of The National Academy of Science USA92:8171-8175.
Dür
Hecht Sidney M.
Miller Guy M.
Edison Pharmaceuticals, Inc.
Morrison & Foerster / LLP
Witherspoon Sikarl A.
LandOfFree
Tail variants of redox-active therapeutics for treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tail variants of redox-active therapeutics for treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tail variants of redox-active therapeutics for treatment of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4003871