Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1981-10-21
1984-03-13
Turk, Arnold
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
422 68, 436533, 436534, 436829, G01N 3354, G01N 3356
Patent
active
044368267
ABSTRACT:
An immunoassay method for measurement of the content of a target antigen or antibody in a fluid or tissue specimen comprises reacting the target with reagent antibody or antigen which forms a complex with the target and is tagged with tagging elements which are unassociated chemically with said reagent and are protected against reaction with the target and the biological and chemical environment of the assay. Preferably the reagent antibody or antigen is carried by small, tagged mobile units, such as latex particles of a size smaller than 0.8 .mu.m, having tagging elements embedded therein. The tagged complexes which are formed may be measured by X-ray fluorescence or by detection of radioactive decay. Different target antigens or antibodies can be assayed simultaneously by employing different tagged mobile units, and the mobile units with the tagging elements can be recovered for disposal or for reuse.
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Ron Jenkins et al., "Quantitative X-ray Spectrometry", Marcel Dekker, Inc., New York, and Basel, 1981, pp. 101-107.
"Practical Radioimmunoassay", A. J. Moss, Jr., 1976, the C. V. Mosby Co., St. Louis, Mo., p. 139.
Turk Arnold
Wang Associates
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