Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1979-03-28
1981-08-04
Randolph, John D.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
71 89, C07D30777
Patent
active
042821541
ABSTRACT:
As per invention, [6--.sup.3 H] or [6--.sup.2 H] gibberellins respectively are produced. By the process as per invention, production of tagged gibberellins is made from natural gibberellins or gibberellin derivatives having a carboxyl group at position 6 of the ent-gibberellin basic skeleton. After transformation into a gibberellin derivative with a hydroxymethyl group at position 6, oxidation is made to gibberellin-7-aldehyde with subsequent conversion of same to a mixture of 6-epimeric gibberellin-7-aldehydes, which will be obtained tagged at the C-6 position if deuterium or tritium donors are present during epimerization, oxidation into tagged gibberellins being performed thereafter.
By the invention, tagged gibberellins are made available which are tritiated or deuterated to such a C-H bond as is present in unsubstituted state in all natural gibberellins and their derivatives, and at which bond no biochemical changes have hitherto been observed.
The process as per invention is of general applicability and produces the tagged gibberellins with a high yield. The process is particularly suitable for compounds with acid-sensitive structure characteristics, for example with simultaneous presence of a hydroxyl group at the C-13 position and of a .DELTA. 16.17 double bond.
REFERENCES:
Murofushi et al., Agric. Biol. Chem., 38(2), 475-476, 1974, S583 A37.
Murofushi et al., Agric. Biol. Chem., 41(6), 1075-1079, 1977, S583 A37.
Adam Gunter
Lischewski Manfred
Akademie der Wissenschaften DER
Fan Jane T.
Randolph John D.
Striker Michael J.
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