Taga gene and methods for detecting predisposition to peptic ulc

Details Taga gene and methods for detecting predisposition to peptic ulc Taga gene and methods for detecting predisposition to peptic ulc

1993-04-26

1995-04-04

Parr, Margaret

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 237, C07H 2102, C07H 2104

Patent

active

054039240

ABSTRACT:
The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic fragment of the present invention and detecting the reaction of the antigen or fragment and the antibody. A mutant H. pylori not expressing a functional tagA antigen is also provided.

REFERENCES:
Prewett et al., Gastroenterology 102:829-833 (1992) "DNA patterns of Helicobacter pylori isolated". . .
Tummuru et al., Astr. Gen. Meet. Am. Soc. Microbiol "Molecular cloning of a unique antigen". . .
Labigne et al., J. Bact. 173:1920-1931 (1991) "Shuttle cloning and nucleotide sequences". . .
Xiang et al. Lancet i:900-901, 1993.
Crabtree et al., J. Clin. Pathol. 45:733-734, 1992.
Gerstenecker et al. Eur. J. Clin. Microbiol. Infect. Dis., 11(7):595-601, Jul. 1992.
Timothy L. Cover and Martin J. Blaser J. Biol. Chemistry, 267(15):10570-10575, May 1992.
Crabtree et al., J. Clin. Pathol., 45:733-734, 1992.
Cover et al., J. Clin. Investigation 90:001-006, 1992.
Crabtree et al. Digestive Diseases & Sciences, 36(9):1266-1273, Sep. 1991.
Crabtree et al. The Lancet, vol. 338:332-335, Aug., 1991.
Cover et al., Infect. & Immunity, 59(4):1264-1270, Apr. 1991.
Cover et al. Infect. & Immunity, 58(3):603-610, 1990.
Hirschl et al., J. Clin. Pathol, 43:511-513, 1990.
Figura et al., J. Clin. Microbio. 27(1):225-226, 1989.
Leunk et al. J. Med. Microbiol. 26:93-99, 1988.
Apel et al. Zbl. Bakt. Hyg., A268:271-276, 1988.
Wulffen et al. J. Clin. Pathol., 41:653-659, 1988.

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