Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-11-06
2007-11-06
Harris, Alana M. (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S004000, C435S007210, C435S007230, C436S063000, C436S064000, C436S164000, C436S166000, C436S174000, C536S001001, C536S018700, C536S022100, C536S023100, C536S023500, C536S024300, C536S024310
Reexamination Certificate
active
10600187
ABSTRACT:
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
REFERENCES:
patent: 5972616 (1999-10-01), O'Brien et al.
O'Brien Timothy J.
Tanimoto Hirotoshi
Adler Benjamin A.
Harris Alana M.
The University of Arkansas for Medical Sciences
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