Tachykinin peptides, precursor peptides thereof and genes...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

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C530S314000

Reexamination Certificate

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10048401

ABSTRACT:
Tachykinin peptide isolated and purified from the posterior salivary gland of the molluskOctopus vulgaris. The tachykinin peptide provides a new approach for developing medicaments and pesticides through studies on the structural activity correlation at the molecular level, is characterized by:(1) number of amino acid residues is 12;(2) N terminal of the peptide is Lys;(3) an amino acid sequence of 5 amino acids from C-terminal is represented by the following amino acid sequence:Phe-Xaa-Gly-Leu-Met (SEQ ID NO: 6),(wherein, Xaa is Val, lie, Phe or Tyr), especially following amino acid sequences are provided:Lys-Pro-Pro-Ser-Ser-Ser-Glu-Phe-Val-Gly-Leu-Met (SEQ ID NO: 1),Lys-Pro-Pro-Ser-Ser-Ser-Glu-Phe-Ile-Gly-Leu-Met (SEQ ID NO: 2).

REFERENCES:
Norinder et al., J. Peptide Res., 1997, 49: 155-162.
Ngo et al., in The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al. (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
Tim Badgery-Parker et al., “Receptor Binding Profile of Neuropeptide γ and Its Fragments: Comparison with the Nonmammalian Peptides Carassin and Ranakinin at Three Mammalian Tachykinin Receptors”, Peptides, 1993, pp. 771-775, vol. 14, USA, XP002287463.
J. Michael Conlon, “Molecular Diversity, Localization, and Biological Actions of Elasmobranch Tachykinins”, Journal of Experimental Zoology, 1999, pp. 535-540, vol. 284, XP008032621.
Ulf Norinder et al., “A Quantitative Structure-Activity Relationship Study of Some Substance P-Related Peptides”, Journal of Peptide Research, 1997, pp. 155-162, vol. 49, Munksgaard International Publishers, ISSN: 1397-002X, XP000679593.
Yasuyuki Shimohigashi et al., “Discriminative Affinity Labeling of Tachykinin NK-1 and Nk-3 Receptors”, Peptide Chemistry, 1993, pp. 337-340, XP1098649.
Iwakoshi E. et al., “Isolation of two novel tachykinins from the posterior salivary gland of Octopus Vulgaris,” Zoological Science (Tokyo) (Dec. 1999), vol. 16, Suppl. p. 103.
Iwakoshi E. et al., “Cardioactive peptides isolated from the brain of Japanese Octopus, Octopus minor,” Peptides (May 2000), vol. 21, No. 5, pp. 623-630.
Martin R. et al., “The neurosecretory system of the octopus vena cava: (A) neurohemal organ,” Experientia (1987), vol. 43, No. 5, pp. 537-543.
Champagne D. E. et al., “Sialokinin I and II: Vasodialatory tachykinins from the yellow fever mosquito aedes aegypti,” Proc. Natl. Acad. Sci. USA (1994), vol. 91, No. 1.
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