Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-10-08
1998-02-10
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514438, 514444, 514461, 514477, 546249, 546255, 548469, 549 29, 549 49, 549429, 549434, A61K 3127, C07D30770, C07D30779, C07D33326
Patent
active
057169799
ABSTRACT:
The invention concerns tachykinin antagonists. The compounds are nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases of the central nervous system, and migraine. Methods of preparing compounds and novel intermediates are also included.
The compounds are expected to be especially useful in asthma and rheumatoid arthritis.
REFERENCES:
patent: 4000297 (1976-12-01), Rovati et al.
patent: 5138061 (1992-08-01), Belleau et al.
patent: 5346907 (1994-09-01), Kerwin, Jr. et al.
patent: 5565568 (1996-10-01), Cho et al.
D. Rehbinder, et al., Ann Chem, 1965, 681:182-7.
H. Nesvadba, Monaish, 1962, 93:386-96.
Hanson, et al., J. Biol Chem, 1949, 179:815-817.
Physiological Reviews, 67 (4) :1117-1142 (1987), S. Nakanishi, "Substance P Precursor and Kininogen . . . ".
Neurochem. Int., 18 (2):149-165 (1991), S. Guard et al. "Tachykinin Receptor Types, Classification and . . . ".
Annu. Rev. Neurosci., 14:123-136 (1991), S. Nakanishi, "Mammalian Tachykinin Receptors".
Pharmacological Reviews, 35 (2):85-141 (1983), B. Pernow, "Substance P".
Current Opinion in Therapeutic Patents, 1:197 (1991), B. E. Tomczuk et al. * (copy to be mailed as soon as availab).
Science, 251:435-437 (1991), R. M. Snider et al., "A Potent Nonpeptide Antagonist of the Substance P . . . ".
Proc. Natl. Acad. Sci., 88:10208-10212 (1991), C. Garret et al., "Pharmacological properties of a potent . . . ".
Brit. J. Pharmacol., 105:78 (1992), N. Watson et al., "Demonstration of a Facilitatory Role of . . . ".
Neuropeptides, 22:24 (1992), T. Fujii et al., "Effect of Novel Substance P Antagonist, FK888, on Airway . . . ".
Tomczuk, B.E. et al. Current Opinions in Therapeutic Patents 1991;1:197.
Horwell David Christopher
Howson William
Pritchard Martyn Clive
Rees David Charles
Roberts Edward
Anderson Elizabeth M.
Oswecki Jane C.
Richter Johann
Warner-Lambert & Company
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