Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-10-08
1999-11-09
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548491, 548496, 549 29, 549 49, 549 56, 549 58, 549 59, 549429, 549462, C07D20904, C07D20918, C07D20920, C07D40506
Patent
active
059817550
ABSTRACT:
The invention concerns tachykinin antagonists. The compounds are nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases of the central nervous system, and migraine. Methods of preparing compounds and novel intermediates are also included. The compounds are expected to be especially useful in asthma and rheumatoid arthritis.
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Neurochem. Int., 18(2):149-165 (1991), S. Guard et al. "Tachykinin Receptor Types, Classification and . . . ".
Annnu. Rev. Neurosci., 14:123-136 (1991), S. Nakanishi, "Mammalian Tachykinin Receptors".
Pharmacological Reviews, 35(2):85-141 (1983), B. Pernow, "Substance P".
Current Opinion in Therapeutic Patents, 1:197 (1991), B. E. Tomczuk et al..
Science, 251:435-437 (1991), R. M. Snider et al., "A Potent Nonpeptide Antagonist of the Substance P . . . ".
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Brit. J. Pharmacol., 105:78 (1992), N. Watson et al., "Demonstration of a Facilitatory Role of . . . ".
Neuropeptides, 22:24 (1992), T. Fujii et al., "Effect of Novel Substance P Antagonsit, FK888, on Airway...".
Tomczuk, B.E. et al. Current Opinions in Therapeutic Patents 1991;1:197.
Horwell David Christopher
Howson William
Pritchard Martyn Clive
Rees David Charles
Roberts Edward
Anderson Elizabeth M.
Oswecki Jane C.
Richter Johann
Warner-Lambert & Company
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