Tablets having improved bioadhesion to mucous membranes

Details Tablets having improved bioadhesion to mucous membranes Tablets having improved bioadhesion to mucous membranes

1987-08-31

1990-04-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424464, 424499, A61F 1300

Patent

active

049159488

ABSTRACT:
A tablet having improved bioadhesion to mucous membranes is disclosed. The tablet comprises effective amounts of a water-soluble biopolymer selected from the group consisting of a xanthan gum, a pectin and mixtures thereof; and a solid polyol having a solubility at room temperature in water greater than about 20 grams of polyol per 100 g of solution. Preferably the biopolymer is xanthan gum and the polyol is a sugar alcohol selected from the group consisting of sorbitol, xylitol, and mixtures thereof.

REFERENCES:
patent: 3911099 (1975-10-01), DeFoney et al.
patent: 3996934 (1976-12-01), Zaffaroni
patent: 4226848 (1980-10-01), Nagai et al.
patent: 4250163 (1981-09-01), Nagai et al.
patent: 4286592 (1981-09-01), Chandrasekaran
patent: 4292299 (1981-09-01), Suzuki
patent: 4572832 (1986-02-01), Kigasawa
patent: 4597959 (1986-07-01), Barr
patent: 4615697 (1986-10-01), Robinson

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