Tablets exhibiting reduced drug release variability

Details Tablets exhibiting reduced drug release variability Tablets exhibiting reduced drug release variability

2011-03-01

2011-03-01

Haghighatian, Mina (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C424S465000, C424S468000, C424S480000, C424S488000, C514S741000

Reexamination Certificate

active

07897172

ABSTRACT:
A compressible extended release tablet or tablet layer having a drug release profile that is not strongly dependent on tablet hardness may be prepared by dry blending a pharmaceutically active ingredient with hydroxypropyl methylcellulose, wherein the hydroxypropyl methylcellulose has a bimodal or multimodal number average molecular weight distribution that includes at least one mode over 20,000 Daltons and at least one mode under 10,000 Daltons. An additional advantage of the invention is that the tablet formulations may be prepared without resort to wet granulation.

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