Boots – shoes – and leggings
Patent
1976-08-13
1978-07-11
Morrison, Malcolm A.
Boots, shoes, and leggings
73 885R, 209 79, 264109, 425149, 425352, G06F 1500, B28B 300, B29C 306
Patent
active
041005988
ABSTRACT:
There is disclosed a method and apparatus for developing and controlling pharmaceutical granulations from a tabletting characteristics standpoint, involving instrumenting a tablet press to derive both the peak compression force and peak ejection force information for each tabletting event in convenient digital form. The thusly derived compression and ejection force information is automatically scaled to desired units of force and utilized in compression and ejection profiles and in the calculation of the average and standard deviations for both compression and ejection in the pursuit of optimization of the tabletted granulation regarding such tabletting characteristics as compressibility, lubricity, relative flow, compression failure point, and tendency of the formed tablets to adhere to the tablet press punches. In addition to the capability of distinguishing between the large-magnitude compression peaks and the relatively very small-magnitude ejection force peaks in the raw analog signal generated from a force transducer mounted on the tablet press, there is provided the capability of measuring ejection force peaks relative to a plurality of selectable reference levels, which enables the granulation formulator to take into account the residual force aspects found to exist following compression and prior to ejection of a formed tablet.
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E. L. Knoechel et al., "Instrumented Rotary Tablet Machines I-Design, Construction, and Performance as Pharmaceutical Research and Development Tools," J. Pharm. Sci., vol. 56, Jan. '67, No. 1, pp. 109-115.
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Browski Charles Robert
Neugroschel Eric
Stiel Donald Melvyn
Williams Joseph James
Gould George M.
Hoffmann-La Roche Inc.
Hopkins Mark L.
Krass Errol A.
Morrison Malcolm A.
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