Tablet formulation

Details Tablet formulation Tablet formulation

1978-04-14

1980-06-24

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424229, 424251, 424361, 424362, A61K 4700

Patent

active

042095131

ABSTRACT:
A tablet suitable for use in the treatment of microbial infections, which tablet comprises from 80 to 98% (w/w) of a combination of a 2,4-diaminopyrimidine with a sulphonamide and not more than 20% (w/w) of both a granulating and a disintegrating agent, the combination having a particle size less than 40 .mu.m and the disintegrating agent having a swelling capacity greater than 5 ml/g.

REFERENCES:
patent: 3034911 (1962-05-01), McKee et al.
patent: 3424842 (1969-01-01), Nurnberg
patent: 3619292 (1971-11-01), Brouillard et al.
patent: 3622677 (1971-11-01), Short et al.
patent: 3632778 (1972-01-01), Sheth et al.
patent: 3639169 (1972-01-01), Broeg et al.
patent: 3679794 (1972-07-01), Bentholm et al.
patent: 3725556 (1973-04-01), Hanssen et al.
patent: 3852421 (1974-12-01), Koyanagi et al.
Fincher, J. Pharm. Sci. 57(11): 1825-1835, Nov. 1968, "Particle Size of Drugs and its Relationship to Absorption and Activity".
P.D.R. 28th Ed. (1974) Physicians Dest Reference, pp. 658-659, ("Septra" B-W), pp. 1215-1216, ("Bactrim" H. LaRoche).
Mendell Mfg. Chemist, Apr. 1972, "Direct Compression Method of Producing Solid Dosage Forms".

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