Tablet for the controlled release of active agents

Details Tablet for the controlled release of active agents Tablet for the controlled release of active agents

1998-06-29

2000-03-07

Dees, Jose' G.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424468, 424469, 424470, 424472, 424474, 424475, A61K 920

Patent

active

060336854

ABSTRACT:
The present invention provides a tablet for the controlled release of an active agent comprising (a) a matrix layer comprising an active agent embedded in a non-swelling, non-gelling hydrophobic matrix; (b) a first barrier layer laminated to a single face of the matrix layer; and (c) an optional second barrier layer laminated to the opposite face of the matrix layer and oppositely disposed to the first barrier layer; wherein the matrix comprises up to about 80% active agent and from about 5% to about 80% by weight of nonswellable waxes or polymeric material insoluble in aqueous medium, and the first and second barrier layers independently comprise (1) polymeric material exhibiting a high degree of swelling and gelling in aqueous medium or (2) nonswellable wax or polymeric material insoluble in aqueous medium.

REFERENCES:
patent: 4756911 (1988-07-01), Drost et al.

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