Tablet for pharmaceutical use able to release active substances

Details Tablet for pharmaceutical use able to release active substances Tablet for pharmaceutical use able to release active substances

1987-12-30

1989-09-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424470, 424471, 424472, 424480, 424482, 427 3, A61K 946

Patent

active

048658499

ABSTRACT:
A tablet for pharmaceutical use able to release active substances at successive times, comprising at least; a first layer containing a portion of the active substance with suitable excipients, a barrier layer of polymer material gellable and/or soluble in water and/or aqueous liquids, which is interposed between said first layer and a third layer containing the remaining portion of active substance with suitable excipients, said barrier layer and said third layer being housed in a casing consisting of polymer material impermeable and insoluble in water or soluble in an alkaline environment.
That part of the active substance not inserted in the casing is immediately available for dissolving, whereas the part inserted in the casing is available only after dissolution or rupture of the barrier layer and/or after solubilization of the casing.

REFERENCES:
patent: 3317394 (1967-05-01), Fryklof et al.
patent: 4139589 (1979-02-01), Beringer et al.
patent: 4267138 (1981-05-01), Dobo et al.
patent: 4753790 (1988-06-01), Silva et al.
patent: 4756911 (1988-07-01), Drost et al.

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