Tablet containing an enzymatically converted starch derivative e

Details Tablet containing an enzymatically converted starch derivative e Tablet containing an enzymatically converted starch derivative e

1998-10-23

2000-07-11

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424466, 424405, 424408, 424400, 536105, 536106, 536102, A61K 920, A61K 946, A61K 900, A01N 2500, C08B 3160

Patent

active

060869178

ABSTRACT:
The present invention is directed to a tablet, particularly a pharmaceutical dosage form, which contains an encapsulating agent comprising a modified starch which is prepared by enzymatic hydrolysis of a starch molecule after the preparation of a starch derivative containing a hydrophobic group or both a hydrophobic and a hydrophilic group, particularly octenyl succinic anhydride starch hydrolyzed by .beta.-amylase or glucoamylase. Such starch allows for good compressibility and hardness of a pharmaceutical dosage form. In addition, the starch may consistently allow for high load and retention of a variety of active agents as well as oxidative resistance.

REFERENCES:
patent: 3455838 (1969-07-01), Marotta et al.
patent: 4035235 (1977-07-01), Richards et al.
patent: 4689235 (1987-08-01), Barnes et al.
patent: 4845035 (1989-07-01), Fanta et al.
patent: 5185176 (1993-02-01), Chiu
patent: 5194284 (1993-03-01), Chiu et al.
patent: 5445950 (1995-08-01), Kobayashi et al.
patent: 5468286 (1995-11-01), Chiu et al.

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