Tablet composition for drug combinations

Details Tablet composition for drug combinations Tablet composition for drug combinations

1989-01-30

1989-09-05

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424488, 424489, 514 29, 514601, 514781, A61K 920, A61K 926, A61K 3118, A61K 3171

Patent

active

048637416

ABSTRACT:
A tablet providing enhanced delivery of an acid-sensitive drug in conjunction with an acid-stable drug is disclosed. The tablet is made up of a matrix containing a major proportion of an acid-stable drug, and a minor proportion of microcrystalline cellulose. Embedded in the matrix are coated granules containing at least about 90% of an acid-sensitive drug by weight, exclusive of the coating, and having a particle size of from about 10 to about 40 mesh. The granules of acid-sensitive drug have an acid resistant and/or enteric coating selected to dissolve in less than sixty minutes at a pH of 5.5 or greater.

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