Tablet composition and method for problem pharmaceutical materia

Details Tablet composition and method for problem pharmaceutical materia Tablet composition and method for problem pharmaceutical materia

1991-05-28

1992-08-11

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424464, 424470, 424489, 514784, 514960, A61K 914, A61K 920

Patent

active

051377306

ABSTRACT:
In accordance with the present invention an improved tablet composition for drugs or active ingredients prone to poor tabletting properties is disclosed. The improved composition comprises a premixture, consisting essentially of between about 85 and 99.9 percent by weight of the active ingredient and between about 0.1 and 15 percent by weight of citric acid, and one or more other formulation ingredients added to premixture. The present invention also involves the process for making such compositions and products therefrom.

REFERENCES:
patent: 4808413 (1989-02-01), Joshi et al.
patent: 4942039 (1990-07-01), Duvall et al.
patent: 4950484 (1990-08-01), Olthoff et al.
Pharmaceutical Dosage Forms, Tablets, vol. 1, 2nd Edition, pp. 188 and 189.
Botzolakis et al., Oct. 1988 AAPS meeting, PT 1691.
Kuhn et al., Oct. 1988 AAPS meeting, PT 1699.

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