Tablet composition

Details Tablet composition Tablet composition

2005-01-18

2005-01-18

Spear, James M. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C424S465000, C514S777000, C514S781000

Reexamination Certificate

active

06844008

ABSTRACT:
A tablet composition containing N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine and a disintegrant, selected from a low substituted hydroxypropylcellulose, sodium carboxymethyl cellulose, calcium carboxymethyl cellulose and sodium croscaramellose sodium, is disclosed. This tablet composition is rapidly disintegrated in the stomach after the administration and absorbed without being influenced by meals to inhibit the rise of the blood sugar levels of diabetics after meals.

REFERENCES:
patent: 4816484 (1989-03-01), Toyoshima et al.
patent: 6143323 (2000-11-01), Yabuki et al.
patent: 6296872 (2001-10-01), Yabuki et al.
The United States Pharmacopeia, p. 2238, Jan. 1995.
Pharmaceutical Macromolecular Material Science, pp. 77-79, Chinese Medicament Science & Technology Press, Apr. 30, 1993.
Statement of Clinical Testing, Mar. 1995.
Y. Kawashima, et al., Chemical and Pharmaceutical Bulletin, vol. 41, pp. 1827-1831, XP-000412579, “Preparation of a Sustained-Release Matrix Tablet of Acetaminophen with Pulverized Low-Substituted Hydroxypropylcellulose via Dry Granulation”, 1993.

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