Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1999-09-29
2000-10-31
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 6, 435 71, 536 231, 530300, 530350, C12Q 168, G01N 3353, C07H 2104, C12N 900, C07K 500
Patent
active
061400424
ABSTRACT:
TAB1 protein having activity which activates factor TAK1 in the TGF-.beta. signaling pathway, and having the amino acid sequence shown in FIG. 1.
REFERENCES:
Shibuya, et al., "Is AMK-1 a Transfer Molecule Involved in TGF-.beta. Signal Transduction," 68th Meeting Of Japanese Society (Sep. 15-18, 1995; Summary Published Jul. 25, 1995 Sendai, Japan).
Nishida, et al, ."Signaling Pathways and Functions of the MAP Kinase Superfamily," 54th Meeting Of Japanese Cancer Association, (Oct. 3-5, 1995 Koyoto, Japan).
Irie, et al., "A Novel Member of MAPKK, TAK1, May Function As A Mediator In TGF-.beta. Signal Transduction," 18th Meeting Of Japanese Molecular Biochemistry Society S21-4 and 2E11, Dec. 6-9, 1995 Nagoya, Japan.
Yamaguchi, et al., "Identification of a Member of the MAPKK Family as a Potential Mediator of TGF-.beta. Signal Transduction," Science 270:2008-11 (1995).
Shibuya, et al., "TAB1: An Activator of the TAK1 MAPKKK in TGF-.beta. Signal Transduction," Science 272: 1179-82 (1996).
Matsuomoto Kunihiro
Nishida Eisuke
Chugai Seiyaku Kabushiki Kaisha
McGarry Sean
Schwartzman Robert A.
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